主要科研成果与奖励（主持项目、获奖、著作、代表性论文） 近年来，围绕着影响国民健康的“心血管疾病”研究领域，先后主持国家自然科学基金项目2项，山东省自然科学基金优秀青年项目1项，山东省高等学校青年创新团队发展计划1项，山东省科技发展计划1项，山东省优秀中青年科技家奖励计划1项，同时，深入企业进行科技攻关，主持生物医药相关企业委托技术课题9项，获得授权国家发明专利5项，研究成果发表在国际期刊Acta Physiol (Oxf), Free Radic Biol Med.等杂志，为相关疾病的治疗提供了新的策略。 代表性论文： 1. Meng Ning, Xie Hong-Xu, Hou Jia-Rong, Chen Yon-Bin, Wu Meng-Jun, Guo Yue-Wei, Jiang Cheng-Shi. Design and semisynthesis of oleanolic acid derivatives as VEGF inhibitors: Inhibition of VEGF-induced proliferation, angiogenesis, and VEGFR2 activation in HUVECs. Chin J Nat Medicines 2022, 20(3), 229-240. 2. Meng N*, Gong Y, Mu X, Wang YH, Su L, Jiang CS and Zhang H. Novel role of Heterogeneous nuclear ribonucleoprotein E1 in regulation of apoptosis and autophagy by a triazole derivative in vascular endothelial cells. International journal of biological sciences. 2019. Doi:10.7150/ijbs32677 3. Meng N, Tang H, Zhang H, Jiang C, Su L, Min X, Zhang W, Zhang H, Miao Z, Zhang W, Zhuang C. Fragment-growing guided design of Keap1-Nrf2 protein-protein interaction inhibitors for targeting myocarditis. Free Radic Biol Med. 2018 Mar;117:228-237. 4. Meng N, Peng N, Huang S, Wang SQ, Zhao J, Su L, Zhang Y, Zhang S, Zhao B, Miao J. Heterogeneous nuclear ribonucleoprotein E1 regulates protein disulphide isomerase translation in oxidized low-density lipoprotein-activated endothelial cells. Acta Physiol (Oxf). 2015 Mar;213(3):664-75. |
