近 3 年围绕肿瘤、糖尿病、儿童罕见病等疾病与齐鲁医院、省立医院、千佛山医院、济南 市儿童医院等单位合作,开展先导化合物的发现、疾病前期检测、药物结构修饰等方面的临床合作, 在 Analytical Chemistry、Acs Sensors、Sensors and Actuators B: Chemical、Food Research International、 Analytical Chimica Acta 等一区 top 期刊以一作或通讯身份发表论文 8 篇。与龙大美食集团、春雪集团、康华生物、水发集团、宏济堂、科源制药、国和堂、莱玉化工等知名企业合作共同进行科研攻关及转化,签署直接经费 300 余万。 近 近 3 年主要主持的纵向项目有: 1 、山东省自然基金面上项目“用小分子化合物拮抗 CCR5 干预 DCM 心肌纤维化的机理研究” (2020年); 2 、山东省自然博士基金“C7 基因不同转录本编码蛋白在乳腺组织的表达及抗金黄色葡萄球菌活性的研究”(2022年)。 3、山东省重点研发计划(乡村振兴科技创新提振行动计划)子课题“白羽肉鸡高效高值关键技术集成创新与示范”(2023年)。 4、山东省重点研发计划(乡村振兴科技创新提振行动计划)核心成员“生猪高效高值关键技术集成创新与示范”(2023年)。 5、山东省科技型中小企业创新能力提升工程项目“中草药药渣发酵工艺优化及在泌乳母猪上的应用研究”(2023年)。 近 3 年以一作或通讯发表的 SCI 代表作: 1、Jin ,Y.; , Yan, L.; , Hui ,Z.; , Wenmin ,H.; Xia, Li.*; Lei, Z.*, Potential alteration enabled peptide elongation for directserum detection of S100B in the early screening of phenylketonuria. Sensors and Actuators: B. Chemical 2023, 134577.(通讯,一区TOP IF=8.4) 2、Longhua, D.; Meihui, Hou.; Hao, L.*; Lei, Z.*; Ya, Cao.*, Photosensitive Peptide Enabling Molecular Recognition Tandem Covalent Biosensing for Evaluating and Preventing Venous. Analytical Chemstry. 2023, 15950-15955.(通讯,一区TOP IF=7.4) 3、TLiu, S.#; Li, K.#; Zhao, Y.; Wang, W.; Bao, J.; Wang, X.; Shi, L.; Zhou, L.*; Fu, Q.*, Fermented Gynochthodesofficinalis (FCHow) Razafim. &B.Bremer alleviates diabetic erectile dysfunction by attenuating oxidativestress and regulating PI3K/Akt/eNOS pathway. Journal of Ethnopharmacology 2023, 307.(通讯,二区IF=5.4) 4、Liu, H.*; Zhang, X.; Cui, Z.; Ding, Y.; Zhou, L.*; Zhao, X.*, Cold plasma effects on the nutrients and microbiological quality of sprouts. Food Research International 2022, 159.(通讯,一区TOP IF=8.1 ) 5、Zhou, L.*; Hou, W.; Wang, Y.; Lin, X.; Hu, J.; Li, J.; Liu, C.*; Liu, H.*; Li, H.*, An extracellular matrix biosensing mimetic for evaluating cathepsin as a host target for COVID-19. Analytica Chimica Acta 2022, 1225. (一作,通讯,一区TOP IF=6.2) 6、Zhou, L.#; Liu, Y.#; Sun, H.; Li, H.; Zhang, Z.*; Hao, P.*, Usefulness of enzyme-free and enzyme-resistant detection of complement component 5 to evaluate acute myocardial infarction. Sensors and Actuators B-Chemical 2022, 369. (通讯,一区TOP IF=8.4) 7、Zhou, L.; Hao, P.; Li, H.*; Zhang, Z.*, Electrochemical Resonance of Molecular Motion Enabling Label-, Antibody-, and Enzyme-Free Detection of SARS-CoV-2. Acs Sensors 2021, 6 (4), 1613-1620. (一作,一区TOP IF=8.9) 8、Zhou, L.; Han, Y.; Kang, L.; Gai, Z.; Li, X.*; Liu, C.*, A Metal Ion-Controlled Molecular "Open Bridge" Detecting Oxidative Stress-Disrupted Apoptotic Signaling in Pediatric Neuroblastoma. Acs Sensors 2021, 6 (12), 4499-4506. (一作,一区TOP IF=8.9) 9、Cheng, W.#; Zhou, L.#; Hu, K.; Kong, D.; Huang, W.; Xu, C.; Li, H.*; Li, J.*, Enzyme-Initiated Assembly of an Extracellular-Like Two-Dimensional Nanonetwork as a Method to Detect Procancerous Activity. Acs Sensors 2021, 1815-1822. (共一,一区TOP IF=8.9) 10、Zhou, L.*; Li, J.*; Zhang, K.; Shi, L.; Qin, S.; Li, H.*, Enabling Molecular Gapping and Bridging on a Biosensing Surface via Electrochemical Cross-Linking and Cleavage. Analytical Chemistry 2020, 92 (3), 2635-2641. (通讯,一区TOP IF=7.4)
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